Essay --

Mid Term Assignment - Genzyme HIMP6170 – Professor Aditya Pai Shweta Harwalkar (ID: 212294831) 2/13/2014 â€Æ' Company / portfolio for analysis (Refer to Appendix 1, 2, 3 & 4) Genzyme Corporation (Genzyme), a subsidiary of Sanofi-aventis, is a biotechnology company which is principally engaged in developing products and services for rare genetic disorders. The company has its operations worldwide with its principal concentration in the US and the UK. Genzyme is headquartered in Massachusetts, the US. The parent company, Sanofi, is a global and diversified healthcare leader. Genzyme is currently organized into two business units – Rare Diseases and Multiple Sclerosis. ïÆ'Ëœ Rare Diseases: Focusing on uncommon and underserved medical conditions, the Rare Disease business unit is currently focused on three medical areas: †¢ Genetic Diseases - Pioneering Solutions to Lysosomal Storage Disorders – Orphan drugs †¢ Endocrinology - genetically engineered version of thyroid-stimulating hormone (TSH) †¢ Cardiovascular Disease - inherited disorders, such as familial hypercholesterolemia, a genetic and potentially life-threatening form of severely high cholesterol that often doesn't respond to traditional treatments ïÆ'Ëœ Multiple sclerosis: Multiple sclerosis is a chronic disease that affects each person differently, with symptoms ranging from numbness in the limbs or forgetfulness to paralysis or loss of vision. Revenues and growth trends (Refer to Appendix 5) Sanofi acquired Genzyme for $20.1 billion. â€Å"New Genzyme† was successfully integrated resulting in sales growth of 16.9%. Sales for Fabrazyme ® (agalsidase beta), a treatment for Fabry disease, nearly doubled. Sales for Myozyme ® and Lumizyme ® (alglucosidase alfa), indicated in Pompe d... ...better compensations Shareholders A leader in orphan drug market will attract more shareholders Genzyme must increase economic value created for shareholders Retail Chains Reducing the retail chain can help Genzyme sell at lower price or have higher profit Changes in the retail chain system will probably affect the profit margin of the drug Government Work closely with the government to make sure that the orphan drugs are available in that country/market Government regulates the price of drugs - If Genzyme does not lower the cost of orphan drugs, then it is very likely that government will set a lower price, which will cut Genzyme’s profit Other rare disease associations Communicate effectively and work closely with these rare disease associations Most rare diseases do not have treatment available - High pricing will prevent some patients from getting treatment

HMOs Failing State Standards :: social issues

HMOs Failing State Standards New Yorkers may be covered by one of the nation's most comprehensive health consumer protection laws--but insurers routinely flout it, according to a report released yesterday by New York City Public Advocate Mark Green. Posing as prospective clients, Green's investigators called 12 of the region's health maintenance organizations, including some of the largest on Long Island and in Queens, to get information about their complaint records, lists of covered prescription drugs and medical procedures, and policies on confidentiality and experimental treatments. Although New York's new managed care bill of rights requires health plans to provide the information to both members and potential members, all of the HMOs flunked the test most of the time, with representatives either unwilling or unable to answer the questions. "Five out of six times the HMOs refused to tell one of our callers whether a drug was covered by the HMO," Green said. "Not to know whether the HMO you might join will cover a drug you use monthly is like a computer store refusing to tell you the memory of the computer--or an auto dealership refusing to give you the miles-per-gallon of the Pontiac." "Our callers got extremely frustrated, and their health wasn't even at risk," Greensaid. The survey was conducted in July and August, just months after the New York law went into effect in April. Kevin McGrath--a spokesman for Wellcare, the small plan that had the worst score--said that although he hasn't seen the full report, he is "suspicious" of the survey's methodology because the results were so extreme. "From the results, it looks to me that the survey may be flawed," he said. "The results are hard to believe." [CURE Comment: Not to MCL subscribers, Kevin.] Even Cigna HealthCare of New York, which scored highest on a point system devised by Green, complied with the law only one-third of the time, according to the report. Other top performers were NYLCare Health Plans of New York, which complied 15 percent of the time, and United Healthcare and Oxford, which both complied 14 percent of the time. Prudential HealthCare, MagnaCare/MagnaHealth and WellCare ranked at the bottom of the list, complying less than 5 percent of the time, Green's office said. Health Insurance Plan of Greater New York, Aetna/US Healthcare and Empire Blue Cross and Blue Shield ranked in the middle, complying 20 percent, 16 percent and 13 percent of the time, respectively.

Finding Forrester Film Review Essay

The film Finding Forrester was an interesting, eye-catching, attention grabbing and exciting movie. The writer Mike Rich did a great job of creating the plot to be funny and fast paced. The director of the film, Gus Van neatly directed the scenes characters to make the film more entertaining. Producers Sean Connery, Laurence Mark, and Rhonda Tollefson had made a great decision on investing what they could into this film which was released on December 19, 2000. Jamal Wallace is an inner city kid who is from Bronx, New York and is an exceptionally good basketball player, and is a genius at writing. Always as a C student and not being challenged at his old school because his school sees he is capable of more than what he does, but when he scores highly on his standardized tests, Jamal comes to the attention of the prestigious prep school in New York Manhattan to further his education and play in the school basketball team. One night, Jamal and his friends decided to break into somebodyà ¢â‚¬â„¢s house and steal a letter opener, but a man comes out and frightens Jamal away. Jamal later returns to the old man’s apartment to apologize and retrieved his backpack. Jamal then returns home to find out that the old man had read and written in his journal entrà ©es. When Jamal again returned to the apartment of the old man, he soon befriends the reclusive writer, William Forrester. The friendship leads to William to overcome his reclusiveness and for Jamal to overcome the racial prejudices and pursue his true dream. Forrester helps Jamal to improve and forward his writing, but Jamal’s English teacher does not believe that Jamal is capable writing so well and assumes that Jamal has been cheating. Enraged, Jamal copies some of what Forrester had once written, but he gets caught for plagiarism. In the end Jamal gets Mr. Forester out of his old apartment into the real world to read something that Jamal had written and also to say that he had given Jamal the right to take his ideas. There were many themes displayed throughout the film such as friendship, and overcoming, struggles and obstacles and finding real friends along the way. Bothe William Forrester and Jamal Wallace find friendship in an unlikely way because of their passion for reading and writing. Although they are different form each other, they are drawn together by similar interests. In the movie Finding Forrester, William Forrester would not have been able to confront his fears or reconnect with the world if not for his friendship with Jamal. For example, at one scene at the end of the movie, In Forrester’s Will, Jamal is given a package, keys to Forrester’s apartment, and a letter. In the letter, Forrester thanks Jamal for helping him revive his desire to live. Also the package had the manuscript for Forrester’s second novel, called Sunset, for Jamal to complete onward.] There were many film techniques that the filmmaker had used throughout the movie to explain the theme of friendship and overcoming obstacles and struggles. In addition, the filmmaker used the technique of point of view which is shown in the movie when the camera was trying to make us feel what it was like to see things from the person’s eyes. The setting was in New York City specifically in the Bronx. Shot Aerial was shown when Jamal and his friends were playing basketball; the filmmaker was showing the relationship between Jamal and his friends in the Bronx. A shot, Close-up was shown when Mr. Forrester was looking through the peep hole showing how hard it was for friendship to be form. Shot, slow motion was shown when Jamal’s basketball team was entering the gym for the game. Shot, tracking was used by the filmmaker when he showed the city at the beginning. Sound, Diegetic was show when the boys were at a party and music was playing in the background. Sound, Nondiegetic was shown when Jamal was talking about the girl who heard sounds. Light, back was shown when Jamal was at Mr. Forrester house and stands next to the window. Light, Source was shown in Mr. Forrester’s house there was a lamp in the background. Motif as shown in the film when Jamal starts using the typewriter that Mr. Forrester was using before and it’s significant because on that typewriter is where Jamal learned how to become a better writer. The filmmaker was successful in my eye because he truly captured every little moment Jamal and Mr. Forrester had while on their journey to success in finding a friend and overcoming struggles they face. The film was a well-made movie with great actors. The Film Finding Forrester was a great movie for young adults like to watch because it has a strong theme of how to overcome hurdles and struggles and making new friends along the way. If it was not for William Forrester taking in Jamal Wallace as his protà ©gà ©, Jamal would not be going to a really great school which challenges him and would not become the amazing writer he has become, most importantly made such a good friend like Mr. Forrester. In the movie the filmmaker incorporated the ten film techniques to show how Mr. Forrester and Jamal worked together to help each other out in overcoming obstacles and struggles.

Advantage Of Television Essay

Communication Technology Communication is the imparting or exchanging of information by speaking, writing, or using some other medium. The communications revolution is based on three technologies Telephone Televisions Computer. The history and development of communication technology is one of the ever increasing speed and efficiency of communication over ever greater distance and ever decreasing costs. Telephone: Telephone / Mobile Phone is a system for transmitting voices over a distance using wire or radio, by converting acoustic vibrations to electrical signals. Today we can send a message from one side globe to another in seconds with touch of button via Mobile Phone. Mobile phone become a video-phone, computer, camera, TV, Radio, message minder, MP3 Music player, newspaper map etc. Television: Television is a system for converting visual images (with sound) into electrical signals, transmitting them by radio or other means, and displaying them electronically on a screen. Computer: Computer is an electronic device which is capable of receiving information (data) in a particular form and of performing a sequence of operations in accordance with a predetermined but variable set of procedural instructions (program) to produce a result in the form of information or signals. Telephone: Receiving and Answering Call, We use telephone in our Home, Office. Mobile Phone: Mobile phone is a telephone with access to a cellular radio system so it can be used over a wide area, without a physical connection to a network. We use mobile phone for Make a Call, Receive a Call, Text Messaging, Smart Phone: Smart Phone is a mobile phone that is able to perform many of the functions of a computer, typically having a relatively large screen and an operating system capable of running general-purpose applications. We use Smart Phone for making a Video Call, MMS, Use Internet, sending and receiving Email, use camera for recording. etc. Fax: Fax is an exact copy of a document made by electronic scanning and  transmitted as data by telecommunications links. Advantage of Telephone: Usages: Usages of Television – We use Television as a Mass Media Tele Text Interactive Television increasing speed and efficiency, ever greater distance and ever decreasing cost for use as Tele Tex, Mass Media and easy communication media between consumer & Customer, Government & Public. Because of Television we get up to date news from different part of the world. Computer Usages: A computer is a â€Å"Machine that performs tasks, such as mathematical calculations or electronic communication, under the control of a set of instructions called program.† (Microsoft Encarta 1998) We use computers in many ways that we may not even realise. In business, computers use barcode and scanners to check customers’ credit, to check out goods at a supermarket, and check warehouse supplies. EFT (Electronic Fund Transfer) electronically moves funds in the form of wages and bills between bank accounts. For Travel – Like booking Tickets, Checking Flight etc. Also we use computer for shopping or online Shopping as Ecommerce, Or E-business – Like e-Bay, Amazon Entertainment – We can watch any broadcast program connect Internet with Computer. Culture – Via internet we can published information about our culture to all over the world, we can meet with other national or cultural people. Such as social media site like – Facebook Bebo Twitter Linked In Google plus Pinterest Tumblr. Flickr VK Instagram Everything we use our daily life has advantage and disadvantage which affect our personal life, social life and normal life. Advantage of Telephone: Telephone Technology has increased dramatically over the last few years, making this issue a little more complicated in the post smartphone world. There are many advantages and disadvantages to using the telephone as a method of communication and some of them are more or less pronounced depending on whether you are considering a land line or a cellular phone. The basic advantages to a telephone. Keeping in contact perhaps on a more regular basis, if for example plans have to be changed quickly and a face to face meeting or a letter may take too long For emergency situations, obviously a cellular phone would be especially helpful in this way. It should also be remembered that a phone number is now required for many employment opportunities. Save time & Cost. Also cell phone is technology, having reached such a point as to now be miniaturized computers, offer access to a great deal of information, entertainment and aid for users. Such as Smart Phone became computer competitor and we use smart phone for upload video, download apps, check Email , make a video call using apps like Skype , google talk etc. Disadvantages of Telephone: Many people feel that phones have made life more hectic and work-orientated precisely because of our ability, and growing infatuation, with being connected to our work, friends and businesses twenty four hours a day. However, some research has also shown that the majority of cell phone use in the work places is actually focused on entertainment and social communication. So, instead of communications technology increasing our work load, it may actually be increasing our social obligations instead. However, there are some general disadvantages to both land line and cell phone use as a method of technology. To begin with: Phone communication is less personal in many ways and can lead to miscommunication and misunderstanding As a method of communication it is more expensive than say, talking Phones can raise privacy concerns not just over wire taps. Crossed lines do still happen and familiarity with using a phone can lead to personal conversations taking place in otherwise public settings. Using smart phone people can record and upload video which could be personal and private moment or something like pornography. Which affect our life badly. Also other disadvantage like – Disruptive Prevent face to face conversation Texting – detrimental to writing skill May damage our ability to focus for any length of time Stalking a bullying ( Like cyber bullying uploading offensive or private video picture) Health risk – like radiation These days marketing calls are being a head ache for everyone. Anonymous threats. Sexual abuses. Helps terrorism.

Final study guide peds

Monitor & Co's for balance, Dally weights most Important. Nutrition fluids/delete/internal (gut) feedings/TIP. Medications admit protocol, path, meds dioxin *ion chromo, toxicity =n/v, halo, labs 0. 5-Eng, apical HER. Watch K+ levels(3. 5-5. 5) don't give if hypo because ? Diuretics, morphine Protocols for giving meds to children know weight, give parents s/s side effects, don't regime meds if child thru it up because you don't know how much they got, parents need to know the dos/don't of medications.Don't tell them Its candy. Always start off with your first action being nursing. Example position before 02. Respiratory-remember everything is smaller Nose breathers till 6 weeks(? ) NSA assessment D, nose flaring, grunting, nasal flaring, anxiety (restlessness fidgety or listlessness), tachyon, sweating, BAG, 02 stats.. Interventions position increase head of bed, suction, 02, medication, do in that order. Care of tracheotomy. Know NC, blow by, mask. .NET, et as far as 02 methods. Nur sing care management Pre-pop Postoperative Care Positioning -prone with head turned to the side Careful suctioning, only if necessary NO coughing, clearing throat, blowing nose Inspect all vomits for s/s fresh bleeding Pain management Entitlement as needed Cool water, ice pops no red or brown colored liquids C] No milk or ice cream Neuron Always a change in LOC is right unless it's already In the question. Especially with ICP. Know fontanels.For MS focus on the word document on EBB Corollary Increase In growth hormone after bones have closed C.V.- cardiac defects cyanic ?hyperemia & agnostic= not as severe hyperemia as cyanic pale TWOFOLD, AAA, AS, AURA SODA atrium VOSS ventricle construes aorta PDA closure DAD HP For all of this know top 3 AND, measles, BBC, nursing and perfusion(C)) positioning semi or high fowlers, decrease HOB if in shock or if crease BP to get blood back to the heart. Monitor I & Co's for balance, Daily weights most important.

Who Should Be Responsible for Obesity

Who should be responsible for obesity? When it comes to the topic of America’s social problems, most of us will readily agree that the obesity epidemic is one of the major problems in America’s society now. Where this agreement usually ends, however, is on the question of who is responsible for this problem. Whereas some are convinced â€Å"Don’t Blame the Eater†, that the fast-food industry is responsible, other maintains that is a personal responsibility and what you eat is your business.My feeling on the issue are mixed. I do support Radley Balko’s position that it is a personal responsibility â€Å"What you eat is you business†. However I find that Radley Balko has over looked some issue on the corporation’s side and I also agree with David Zinczenko’s argument that it is corporate responsibility. I agree that in the articleâ€Å"What you eat is your business† Radley Balko  states that â€Å"We’re becoming l ess responsible for our own health, and more responsible for everyone else’s.Your heart attack drives up the cost of my premiums and office visits. And if the government is paying for my anti-cholesterol medication, what incentive is there for me to put down the cheeseburger? † More and more insurance companies are making ton of money every day, Americans rather spend all their money to pay for premiums health policies but not take care of their own health. But why bother to spend all the money on those policies, we can just put down the cheeseburger and save.People  argue that they don't have time to eat healthy but this is only an  excuse, if we all use five  minutes to pack our own lunch that can change a lot in the society, I know we all busy with all kind of different things in our daily life but we have an hour to watch TV but do not have five  minutes to pack lunch? Even a sandwich with a juice box is healthier than those fast-foods in the street. Isnâ₠¬â„¢t it a health body is most important to our life?In â€Å"  What you eat is your business† Radley Balko also claim that â€Å" Instead of manipulating or intervening in the array of food available to American consumers, our government ought to be working to foster a sense of responsibility in and ownership of our own health and well-being. But we’re doing just the opposite. † 61% of American is overweight in America, government, president, politicians and school board try so many things to ban the fast foods and sodas from school campuses and vending machines, but I think those are wrong way to fight obesity.Government and school board should foster people to eat health, teach them how to manage their diet and tell them the outcomes of not take care their own health, not intervening in the array of food available to American consumers. But I also agree David Zinczenko, â€Å"Don’t Blame the Eater† insist that† Drive down any thoroughfar e in America, and I guarantee you’ll see one of our country’s more than 13,000 McDonald’s restaurants. Now, drive back up the block and try to find someplace to buy a grapefruit. † Fast-food restaurants are all over the place, how can we avoid it?When we don’t want to cook or on Sunday some families want to eat outside, there is no other choice for them, drive down any thoroughfare fast food restaurant everywhere. It hard to find places where healthier foods are sold; there are inexpensive and convenient compare to fast-food restaurants. There are also a number of convenient stores everywhere, and convenient stores do not just offer chips and sodas, most of them offer fresh fruits, water and other healthy alternatives to â€Å"fast-food†. People can also choose to eat at home, or carry around a healthy snack that they got at home.Eric Schlosser in â€Å"Your Trusted Friend† emphasize that â€Å" Fast food chains annually spend about $ 3 billion on television advertising, their marketing efforts directed at children extend far beyond such conventional ads. The McDonald’s corporation now operates more than eight thousand playgrounds at its restaurants in the United State. A manufacturer of â€Å"Playlands† explains why fast-food operators to build these largely plastic structures:† Playlands bring children, who bring in parents, who bring in money. † Fast food restaurants become gathering spaces for families with young children.Every about 90 percent of American children between the ages of three and nine visit a McDonald’s. Children are the biggest consumer for fast-food restaurants, that’s way fast-food restaurant spend about $3 billion on television advertising and some other promotion, like buy happy meal with free toys. A successful promotions easily double or triple the weekly sales volume of children’s meals. But other side a successful promotions also easily do uble or triple the chance of being obesity. In my opinion I think fast- food over advertise.Even fast food industry influence of the food market is the biggest reason causing us to have obesity, as a consumer we put everything into our mouth, you can blame the fast food industry and the food available to us all day but you actually is responsible for what you eat. You can find all kinds of excuse, but you still have the responsibility to take care of yourself we need to be aware of the problem first, willing to take a step in choosing the right foods, and make an effort to do exercise without this demand at the first place, no one ethical company has the viability to survive in such a cruel demand driven market.

Changes in Bangladesh

Bangladesh came to today's shape through a long history of political evolution. Bengal was probably the wealthiest part of the subcontinent up till the 16th century. The area's early history featured a succession of Indian empires, internal squabbling, and a tussle between Hinduism and Buddhism for dominance. All of this was just a prelude to the unstoppable tide of Islam which washed over northern India at the end of the 12th century. Mohammed Bakhtiar Khalzhi from Turkistan captured Bengal in 1199 with only 20 men. That was just the beginning. The journey of Bangladesh goes on. Today here I am going to state the changes I have experienced through my life. So it will be a comparison between the last of nineteenth century and the early of twentieth century. It might be a much smaller time limit for a country but still there has been a gigantic change in the life of Bangladeshi people and in Bangladesh. Cultural Change: 1. Earlier most people of Bangladesh used to watch BTV. There were no other channels available then. Now the scenario has changed people are attracted to some foreign channels. Which may not be bad, but some has become addicted to this channels like the Indian channels (serials, movie, songs etc). Also we are watching English movies, songs, serials also. So different cultural practice is going around the country so much in number. 2. Dresses of this country among youth have changed drastically now-a-days it is easy to found western dresses in young people. Foreign culture is introduced largely in this country. Short dresses are worn by women, boys are found in shorts and thus modernization in a western manner. . Celebration of days like Valentine’s Day, friendship day and many other occasions has been celebrated all over the country. People wearing different dress and exchanging gifts on this occasion. 4. Before the cultures we have for instant, ‘pohela boishakh’, ‘pohela falgun ‘ was celebrated in a usual manner but now it has become a greater event to rejoice. The celebration has covered the villages also. Language change: The British Empire ruled the Indian subcontinent for almost 200 years (from 1757–1947). During this colonial period, there are immense changes in the education and cultural sectors of the continent. The impact of the colonial rule also continued to be felt in the postcolonial period. During colonial rule, the changes had influenced immensely the indigenous people in particular. The changes, that took place in the culture and lifestyle of the indigenous groups of Bangladesh during the colonial period was mainly because of their conversion to the Christian religion and involvement in the urban workforce. But there is no doubt that changes in continues to take place in the language & culture of the indigenous people even the postcolonial era. The reasons behind these changes are mainly: destruction of the forests, unemployment, development of communication, interaction with the Bengalis for business purposes, educational expansion etc. It should be noted that, although much modification took place among the indigenous group of people, there was no involvement of the state. The only step has been taken that, a cultural institute was established to look after their language and culture. Regrettably, very little of their cultural life is to be seen in the mass media. In Bangladesh, although decision has been taken for the indigenous group of the people about five years back to allow them to obtain primary education in their own (mother) language; it is yet to take place in reality. The survivals of the indigenous language are now at stake because of the domineering influence of the state language, which is Bengali. Here, some examples of language and cultural changes are presented. 1. Most of the indigenous of Bangladesh had their own language and words. Now, in their everyday life they use 30-40% Bengali words (they also used few English words). 2. Shifting cultivation (Jum chas) was much related with indigenous life and culture of Chittagong Hill Tract (CHT). But in the year 1961 after building the kaptai dam (CHT), 70% of indigenous (CHT) bound to leave this special type of cultivation. As a result, changes have taken place in their folk culture, worship & festival, which were related with shifting cultivation. 3. One of the indigenous of the Bangladesh is called Chakma. They had their own language & script, named ‘Ojhapata’. Now this script is not used, instead they are habituated to Bengali script. Climate Change: As one of the countries most seriously affected by climate change and natural disasters, Bangladesh has been forced to be resourceful and resilient. Without outside help, however, the country of 160 million will not have the capacity to address climate-related environmental changes as their severity and frequency increase. The United States should augment its focus on adaptation measures when providing the South Asian nation with aid. The repercussions of global warming on Bangladesh are diverse and wide-reaching. The environmental changes that are occurring directly affect all aspects of society. Human health, food security, industry and energy security, infrastructure, and economic development are all threatened by climate change. According to the World Bank, 40 percent of foreign aid to Bangladesh is vulnerable to climate-related factors. In a country as densely populated as Bangladesh, even small-scale shifts in ecological systems have a profound humanitarian impact. As the effects of climate change continue to intensify, the potential for social, economic, and humanitarian disaster is rapidly increasing. One of the most serious impacts of climate change is on human migration. As sea levels rise and a vast proportion of Bangladesh becomes inundated, many will have no choice but to flee their homes. Bangladeshi â€Å"land squatters† have for decades settled on vulnerable islands of silt known as chars. already vulnerable during monsoons, this rootless population is sure to increase. With higher sea levels and stronger storms, the chars are quickly eroding under their inhabitants' feet. Farmers who can no longer cultivate their land, inhabitants of coastal areas that have been submerged in sea water, and other impoverished Bangladeshis who are forced to leave their homes to escape from climate change will become environmental refugees. They will spill over into Bangladesh's neighboring countries and may end up in the already crowded slums of cities like Calcutta, Delhi, and Mumbai. Political change: From the very beginning politics of Bangladesh is largely same. One government goes another comes but nothing changes the life of the poor people. The need of development is still a crying need. It has been 40 years but still we could not secure the daily need of food, clothing, shelter, education, medication for everyone. It has been a common promise from every political party that they will do it after winning the election but at the end of the day the result is still same. It’s a real shame for country like us. We have a great history like the liberation war. So it’s very sad for us that political character hasn’t changed yet. Eighteen or twenty years are not a big time. The original culture is still kept in our mind. It is obvious that country’s culture is changing. Culture is such thing that is to be compared with river, it has no end, and it goes on. Therefore we must try to keep our culture clean and must have respect for our culture. It is not build in a day. Cultural history of Bangladesh is very rich. To continue this culture it’s our duty to learn about it. It must be taught in school, what our culture is. At the end I want to say I love my country and have full respect for my culture.